Anhedonia in Parkinson's disease patients with and without pathological gambling: a case-control study.
Identifieur interne : 000B46 ( Main/Exploration ); précédent : 000B45; suivant : 000B47Anhedonia in Parkinson's disease patients with and without pathological gambling: a case-control study.
Auteurs : Mauro Pettorruso [Italie] ; Giovanni Martinotti [Italie] ; Alfonso Fasano [Canada] ; Giovanna Loria [Italie] ; Marco Di Nicola [Italie] ; Luisa De Risio [Italie] ; Lucia Ricciardi [Italie] ; Gianluigi Conte [Italie] ; Luigi Janiri [Italie] ; Anna Rita Bentivoglio [Italie]Source :
- Psychiatry research [ 1872-7123 ] ; 2014.
English descriptors
- KwdEn :
- Aged, Anhedonia, Behavior, Addictive (complications), Behavior, Addictive (psychology), Case-Control Studies, Compulsive Behavior (complications), Compulsive Behavior (psychology), Disruptive, Impulse Control, and Conduct Disorders (complications), Disruptive, Impulse Control, and Conduct Disorders (psychology), Female, Gambling (complications), Gambling (psychology), Humans, Male, Middle Aged, Parkinson Disease (complications), Parkinson Disease (psychology), Pleasure, Reward.
- MESH :
- complications : Behavior, Addictive, Compulsive Behavior, Disruptive, Impulse Control, and Conduct Disorders, Gambling, Parkinson Disease.
- psychology : Behavior, Addictive, Compulsive Behavior, Disruptive, Impulse Control, and Conduct Disorders, Gambling, Parkinson Disease.
- Aged, Anhedonia, Case-Control Studies, Female, Humans, Male, Middle Aged, Pleasure, Reward.
Abstract
Anhedonia is present in Parkinson's Disease (PD) as well as in addictive behaviors. Pathological Gambling (PG) and other Impulse Control Disorders (ICDs) have emerged as iatrogenic complications associated with dopamine replacement therapy. We studied 154 PD patients, divided into three groups: 11 with PG, 23 with other ICDs (compulsive buying, hypersexuality, binge eating), 120 without ICDs. All patients underwent a thorough clinical, neuropsychological and psychiatric evaluation. The PG-group, compared to the ICDs-group and PD-controls, reported a significantly higher incidence of anhedonia (45% vs. 9% vs. 14% respectively), higher Snaith-Hamilton Pleasure Scale (SHAPS) scores (2.0±1.3 vs. 1.0±1.1 vs. 1.0±1.2), higher levels of impulsivity traits as measured by the Barratt Impulsiveness Scale (70.0±10.6 vs. 64.8±11 vs. 60.9±9.3) and more severe frontal dysfunctions (Frontal Assessment Battery, FAB: 12.4±4.9 vs. 15.5±1.6 vs. 14.4±3). A model for PG (incorporating anhedonia, impulsivity levels and frontal impairment) is discussed in the context of the pathophysiology of addictive behaviors. The impairment of hedonic capacity, possibly resulting from an underlying neuropsychological dysfunction, might facilitate loss of control over reward-related behavior, thus favoring the shift towards predominantly habit-based compulsive behaviors.
DOI: 10.1016/j.psychres.2013.12.013
PubMed: 24373553
Affiliations:
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xml:lang="en">Anhedonia in Parkinson's disease patients with and without pathological gambling: a case-control study.</title><author><name sortKey="Pettorruso, Mauro" sort="Pettorruso, Mauro" uniqKey="Pettorruso M" first="Mauro" last="Pettorruso">Mauro Pettorruso</name><affiliation wicri:level="3"><nlm:affiliation>Department of Psychiatry, Drug Addiction Unit, Catholic University of The Sacred Heart, Rome, Italy. Electronic address: mauro.pettorruso@hotmail.it.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Psychiatry, Drug Addiction Unit, Catholic University of The Sacred Heart, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Martinotti, Giovanni" sort="Martinotti, Giovanni" uniqKey="Martinotti G" first="Giovanni" last="Martinotti">Giovanni Martinotti</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurosciences and Imaging, University "G. D'Annunzio", Chieti, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurosciences and Imaging, University "G. D'Annunzio", Chieti</wicri:regionArea><wicri:noRegion>Chieti</wicri:noRegion></affiliation></author><author><name sortKey="Fasano, Alfonso" sort="Fasano, Alfonso" uniqKey="Fasano A" first="Alfonso" last="Fasano">Alfonso Fasano</name><affiliation wicri:level="4"><nlm:affiliation>Movement Disorders Center, TWH, UHN, Division of Neurology, University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Movement Disorders Center, TWH, UHN, Division of Neurology, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Loria, Giovanna" sort="Loria, Giovanna" uniqKey="Loria G" first="Giovanna" last="Loria">Giovanna Loria</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Movement Disorder Unit, Catholic University of The Sacred Heart, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurology, Movement Disorder Unit, Catholic University of The Sacred Heart, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Di Nicola, Marco" sort="Di Nicola, Marco" uniqKey="Di Nicola M" first="Marco" last="Di Nicola">Marco Di Nicola</name><affiliation wicri:level="3"><nlm:affiliation>Department of Psychiatry, Drug Addiction Unit, Catholic University of The Sacred Heart, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Psychiatry, Drug Addiction Unit, Catholic University of The Sacred Heart, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="De Risio, Luisa" sort="De Risio, Luisa" uniqKey="De Risio L" first="Luisa" last="De Risio">Luisa De Risio</name><affiliation wicri:level="3"><nlm:affiliation>Department of Psychiatry, Drug Addiction Unit, Catholic University of The Sacred Heart, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Psychiatry, Drug Addiction Unit, Catholic University of The Sacred Heart, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Ricciardi, Lucia" sort="Ricciardi, Lucia" uniqKey="Ricciardi L" first="Lucia" last="Ricciardi">Lucia Ricciardi</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Movement Disorder Unit, Catholic University of The Sacred Heart, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurology, Movement Disorder Unit, Catholic University of The Sacred Heart, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Conte, Gianluigi" sort="Conte, Gianluigi" uniqKey="Conte G" first="Gianluigi" last="Conte">Gianluigi Conte</name><affiliation wicri:level="3"><nlm:affiliation>Department of Psychiatry, Drug Addiction Unit, Catholic University of The Sacred Heart, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Psychiatry, Drug Addiction Unit, Catholic University of The Sacred Heart, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Janiri, Luigi" sort="Janiri, Luigi" uniqKey="Janiri L" first="Luigi" last="Janiri">Luigi Janiri</name><affiliation wicri:level="3"><nlm:affiliation>Department of Psychiatry, Drug Addiction Unit, Catholic University of The Sacred Heart, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Psychiatry, Drug Addiction Unit, Catholic University of The Sacred Heart, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Bentivoglio, Anna Rita" sort="Bentivoglio, Anna Rita" uniqKey="Bentivoglio A" first="Anna Rita" last="Bentivoglio">Anna Rita Bentivoglio</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Movement Disorder Unit, Catholic University of The Sacred Heart, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurology, Movement Disorder Unit, Catholic University of The Sacred Heart, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author></analytic><series><title level="j">Psychiatry research</title><idno type="eISSN">1872-7123</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Anhedonia</term><term>Behavior, Addictive (complications)</term><term>Behavior, Addictive (psychology)</term><term>Case-Control Studies</term><term>Compulsive Behavior (complications)</term><term>Compulsive Behavior (psychology)</term><term>Disruptive, Impulse Control, and Conduct Disorders (complications)</term><term>Disruptive, Impulse Control, and Conduct Disorders (psychology)</term><term>Female</term><term>Gambling (complications)</term><term>Gambling (psychology)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (psychology)</term><term>Pleasure</term><term>Reward</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Behavior, Addictive</term><term>Compulsive Behavior</term><term>Disruptive, Impulse Control, and Conduct Disorders</term><term>Gambling</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Behavior, Addictive</term><term>Compulsive Behavior</term><term>Disruptive, Impulse Control, and Conduct Disorders</term><term>Gambling</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Anhedonia</term><term>Case-Control Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Pleasure</term><term>Reward</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Anhedonia is present in Parkinson's Disease (PD) as well as in addictive behaviors. Pathological Gambling (PG) and other Impulse Control Disorders (ICDs) have emerged as iatrogenic complications associated with dopamine replacement therapy. We studied 154 PD patients, divided into three groups: 11 with PG, 23 with other ICDs (compulsive buying, hypersexuality, binge eating), 120 without ICDs. All patients underwent a thorough clinical, neuropsychological and psychiatric evaluation. The PG-group, compared to the ICDs-group and PD-controls, reported a significantly higher incidence of anhedonia (45% vs. 9% vs. 14% respectively), higher Snaith-Hamilton Pleasure Scale (SHAPS) scores (2.0±1.3 vs. 1.0±1.1 vs. 1.0±1.2), higher levels of impulsivity traits as measured by the Barratt Impulsiveness Scale (70.0±10.6 vs. 64.8±11 vs. 60.9±9.3) and more severe frontal dysfunctions (Frontal Assessment Battery, FAB: 12.4±4.9 vs. 15.5±1.6 vs. 14.4±3). A model for PG (incorporating anhedonia, impulsivity levels and frontal impairment) is discussed in the context of the pathophysiology of addictive behaviors. The impairment of hedonic capacity, possibly resulting from an underlying neuropsychological dysfunction, might facilitate loss of control over reward-related behavior, thus favoring the shift towards predominantly habit-based compulsive behaviors.</div></front></TEI><affiliations><list><country><li>Canada</li><li>Italie</li></country><region><li>Latium</li><li>Ontario</li></region><settlement><li>Rome</li><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="Italie"><region name="Latium"><name sortKey="Pettorruso, Mauro" sort="Pettorruso, Mauro" uniqKey="Pettorruso M" first="Mauro" last="Pettorruso">Mauro Pettorruso</name></region><name sortKey="Bentivoglio, Anna Rita" sort="Bentivoglio, Anna Rita" uniqKey="Bentivoglio A" first="Anna Rita" last="Bentivoglio">Anna Rita Bentivoglio</name><name sortKey="Conte, Gianluigi" sort="Conte, Gianluigi" uniqKey="Conte G" first="Gianluigi" last="Conte">Gianluigi Conte</name><name sortKey="De Risio, Luisa" sort="De Risio, Luisa" uniqKey="De Risio L" first="Luisa" last="De Risio">Luisa De Risio</name><name sortKey="Di Nicola, Marco" sort="Di Nicola, Marco" uniqKey="Di Nicola M" first="Marco" last="Di Nicola">Marco Di Nicola</name><name sortKey="Janiri, Luigi" sort="Janiri, Luigi" uniqKey="Janiri L" first="Luigi" last="Janiri">Luigi Janiri</name><name sortKey="Loria, Giovanna" sort="Loria, Giovanna" uniqKey="Loria G" first="Giovanna" last="Loria">Giovanna Loria</name><name sortKey="Martinotti, Giovanni" sort="Martinotti, Giovanni" uniqKey="Martinotti G" first="Giovanni" last="Martinotti">Giovanni Martinotti</name><name sortKey="Ricciardi, Lucia" sort="Ricciardi, Lucia" uniqKey="Ricciardi L" first="Lucia" last="Ricciardi">Lucia Ricciardi</name></country><country name="Canada"><region name="Ontario"><name sortKey="Fasano, Alfonso" sort="Fasano, Alfonso" uniqKey="Fasano A" first="Alfonso" last="Fasano">Alfonso Fasano</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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